Biology question

can someone explain why would the answer be D?

Is this on the IMAT spec? If it is I need to revise this asap! - Going on what I know :

Reason its D is because in Downs Syndrome, the zygote has an additional 21 chromosome (whilst also having all the other chromosomes)
A - has additional 15 chromosome instead of 21
B - Wouldn’t have 2 X in the same cell for the formation of an egg
C - Same as above

as far as i know mutations are in the imat syllabus!
thanks for the explanation!

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