Hello, there is a q id like help with:
A section of the coding strand of the DNA sequence of a gene that is expressed in a healthy human liver cell is 5’-ATGCGCCGTAT-3’.
A microRNA (miRNA) regulates this gene by signalling an enzyme to cleave the mRNA corresponding to this section.
What would the sequence be for the miRNA that regulates this gene?
A. 3’-AUGCGCCGUAU-5’
B. 3’-TACGCGGCATA-5’
C. 5’-ATGCGCCGTAT-3’
D. 5’-UACGCGGCAUA-3’
E. 5’-UAGCGCCGUAU-3
Hi
I also fell into this trap when going over the paper 
since we know miRNA regulates gene expression by binding to complementary mRNA it should be 5’ UAG 3’
However i’m not too sure we were supposed to have this level of detailed knowledge to solve the question
“A miRNA regulates this gene by signaling an enzyme to cleave the mRNA corresponding to this section” is worded very badly, but i believe they meant to say:
“an mRNA will be regulated by a miRNA that has the exact same sequence.
When this sequence is presented to the enzyme it will signal it to find others like it and regulate them”
So using the logic of the question, we should be looking for the sequence identical to that of mRNA which is 3’ AUG 5’
thanks for that explanation! I assume that we won’t have questions like that in the imat. unless miRNA will be in the syllabus
