IMAT 2018 Q29 [Reverse Transcriptase]

Reverse transcriptase is mainly found in retroviruses such as HIV. Four nucleotides are needed for the reaction catalysed by this enzyme.

A group of molecules may inhibit this enzyme. These molecules are structurally similar to the nucleotides but slightly altered so that bonds normally formed in the reaction cannot be made.

Which of the following statements may be correct?

  1. The four inhibitor molecules will resemble adenine, thymine, guanine and cytosine.
  2. The inhibitor molecules can prevent the formation of phosphodiester bonds.
  3. The inhibitor molecules can result in a reduction in the number of new virus particles
    produced.

A. 1 and 3 only
B. 1, 2 and 3
C. 3 only
D. 1 and 2 only
E. 2 and 3 only