It confusing. What are your views on this?

What is the primary reason that pH is controlled so tightly in humans?

  1. To allow rapid protein synthesis
  2. To allow for effective digestion throughout GI tract.
  3. To ensure ions can function properly in neural signalling
  4. To prevent changes in electrical charge in polypeptide chains
  5. To prevent changes in core body temperature.
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if we assume by “primary reason” they mean the most general answer than it should be 4 )
My reasoning is that 1 ) and 2 ) depend on depend on 4 ) so this must be the most broad statement

Is this the correct answer?

4 is the correct option . I was confused why it can’t be 1