Urea transportation

how is urea transported from the liver to the kidney?

Urea transporter A1 transports urea across the apical membrane into the intracellular space of luminal cells in the inner medullary collecting duct of the kidneys . Urea is very polar, so it can be just found in the blood.

Yes but I meant does urea go with the blood from hepatic vein→ vena cava → heart → kidney
Is this sequence correct if yes then my question is does urea cross from heart too?

The hepatic veins carry deoxygenated and nutrient-depleted blood from the liver back to the heart via the inferior vena cava. From there, blood is pumped through the right atrium and ventricle to the pulmonary artery, which sends the blood to the lungs for oxygenation. After oxygenation in the lungs, blood returns to the heart via the pulmonary veins into the left atrium and ventricle. Then it is pumped out of the heart to the rest of the body, including the kidneys, via the aorta.

So, if you’re asking about the route that urea (a waste product of protein metabolism) takes to get from the liver (where it’s produced) to the kidneys (where it’s excreted), then yes, that route involves passing through the heart. The sequence would be as follows:

Liver → Hepatic vein → Inferior Vena Cava → Right Atrium of the Heart → Right Ventricle → Pulmonary Artery → Lungs → Pulmonary Veins → Left Atrium → Left Ventricle → Aorta → Kidneys.

The heart, in this case, is simply acting as a pump. It doesn’t filter the blood or remove urea. The kidneys are the organs responsible for filtering the blood and removing waste products like urea, which they excrete as a component of urine. So, while urea does physically pass through the heart, it’s not metabolically processed or removed there.

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Thank you so much , that’s really helpful

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